Blar i forfatter "Holt, jan"

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    • Eculizumab treatment during pregnancy does not affect the complement system activity of the newborn 

      Hallstensen, Randi; Bergseth, Grete; Foss, Stian; Jæger, Steinar; Gedde-Dahl, Thobias; Holt, jan; Christiansen, Dorte; Lau, Corinna; Brekke, Ole Lars; Armstrong, Elina; Stefanovic, Vedran; Andersen, Jan Terje; Sandlie, Inger; Mollnes, Tom Eirik (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-11-13)
      Eculizumab is a humanized IgG2/4 chimeric anti-complement C5 antibody used to treat patients with paroxysmal nocturnal hemoglobinuria (PNH) or atypical hemolytic uremic syndrome. The aim of this study was to evaluate whether or not the complement activity in newborns from pregnant women who receive eculizumab is impaired. A novel eculizumab-C5 complex (E-C5) specific assay was developed and ...

    • Lower respiratory tract infections appear to be the most important risk factor for current asthma in subarctic schoolchildren. 

      Hansen, Tonje Elisabeth; Evjenth, Bjørg; Holt, jan (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-10-01)
      <p><i>Aim - </i>The aim of this study was to identify possible risk factors for current asthma revealed by two studies in Northern Norway in 1985 and 2008 and to evaluate these factors contributing to the increased prevalence of asthma over these 23 years. <p><i>Methods - </i>As part of the ‘Asthma and allergy study among schoolchildren in Nordland county’ we performed a case–control study (70.0% ...